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Brookhuis SAM, et al

Moore A, Morris ID: The involvement of insulin-like growth factor-I in local control of steroidogenesis and DNA synthesis of leydig and non-leydig cells in the rat testicular interstitium

This multi-stage process may eventually lead to the disturbance in the structure of membrane of the vacuole (tonoplast) leading to the leakage of lytic enzymes into the intracellular environment of yeasts causing acidification [2, 38]

secondly, relative to other organs, the brain has lower levels of ROS scavenging enzymes and thirdly the brain is 60% fat a high proportion of which is unsaturated fatty acids that are highly susceptible to lipid peroxidation