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If you have difficulty absorbing vitamin B12 through your digestive system due to pernicious anemia or gastrointestinal disorders, B12 shots may be the better option

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Participants allocated to placebo groups are increasingly likely to withdraw from treatment or to adopt additional measures aimed at weight loss

Consider intramuscular vitamin B 12 injections instead of oral replacement for suspected or confirmed vitamin B 12 deficiency caused by diet if: The person has another condition that may deteriorate rapidly and have a major effect on their quality of life (for example, a neurological or hematological condition such as ataxia or anemia)