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For sulfonylureas, dose reduction or discontinuation should be strongly considered before initiating tirzepatide, as these medications provide diminishing benefit when combined with more effective agents and substantially increase hypoglycemia risk

Patients with OH usually undergo neurologic, cardiologic, and endocrine evaluation, because there are several causes for this presentation

H2S as a possible therapeutic alternative for the treatment of hypertensive kidney injury

Although enhanced glycolysis may transiently support cellular energy demands, it is markedly less efficient in ATP generation and is accompanied by lactate accumulation, increased production of reactive oxygen species (ROS), and activation of multiple metabolic bypass pathways