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Otherwise, there is the milder increases of the pressure in the ligated superior sagittal sinus upon additional volume application in the right external jugular vein or in the inferior caval vein, where in the control rats, the portal/caval hypertension remained unchanged, but contributed to the further raise of the increased pressure in the superior sagittal sinus (Figure 5)

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Without blinding and comparison to placebo, it's impossible to determine how much improvement resulted from the peptide itself versus natural healing, placebo effect, or concurrent treatments

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