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Intracellular signal pathways are involved in numerous biological processes and have also been demonstrated to be intimately linked to the development of drug resistance

J Toxicol Clin Toxicol 41:339347 Veljkovic AR, Nikolic RS, Kocic GM, Pavlovic DD, Cvetkovic TP, Sokolovic DT, Jevtovic TM, Basic JT, Laketic DM, Marinkovic MR (2012) Protective effects of glutathione and lipoic acid against cadmium-induced oxidative stress in rats kidney

Furthermore, steroids like progesterone and estrogen have protective roles in terms of reducing oxidative stress, edema, and inflammation, besides preventing apoptosis and maintaining homeostasis

Four overlapping upregulated genes were screened, including enolase 3 ( ENO3 ), ERO1 , hexokinase ( HK2 ), and SLC7A11 (Fig