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Its a two-way street in IBD, with the gut microbiome changes potentially causing high homocysteine, but then high homocysteine will increase the inflammation in the gut.[ref] Gastrointestinal production of homocysteine: Gut microbes that produce folate: The amount of folate produced by the gut microbiome is on a similar scale to what we get from food, so it is a significant source of folate for most people

M., Craft, S., Merriam, G

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Due to its transmembrane alignment in the lipid bilayer, AST can synergistically interact with other anti-oxidants such as vitamin C, being an acceptor for the radical cations [54]