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Routine follow-up care during treatment with blood tests and physical exam also helps to ensure safety

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As mentioned previously, the widespread and prolonged use of histamine H 2 -receptor blockers and proton pump inhibitors for ulcer disease also may cause impaired breakdown of vitamin B 12 from food, causing malabsorption and eventual depletion of B 12 stores

Oral B12 supplements rely on a complex absorption pathway in the gut involving a protein called intrinsic factor