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In response to these comments, we have increased burden estimates, and as addressed above, have allowed additional flexibility to use an alternative, equivalent source of remittance data to address those concerns

A lack of vitamin B12 can lead to vitamin B12 deficiency anaemia which causes the body to produce abnormally large red blood cells that cannot function properly to carry oxygen around the body, leading to nerve damage or neuropathy

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For those who like a visual pathway, heres what the complete folate and methylation cycle looks like