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Hepatology 32:455460 Mayo JC, Sainz RM, Tan DX, Hardeland R, Leon J, Rodriguez C, Reiter RJ (2005) Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK) in macrophages

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A high proton leakage has been associated with cancer stem cells (CSCs), uncoupling oxidative phosphorylation to control the production of ROS

This truncation results in approximately 10-fold reduction in binding affinity for all six known IGF binding proteins (IGFBP-1 through IGFBP-6) while retaining near-equivalent potency at the IGF-1 receptor