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This use has been supported by a double-blind clinical trial showing that, once alcohol use is stopped, milk thistle can reverse some of alcohol-induced liver damage

Miller V, Mente A, Dehghan M, Rangarajan S, Zhang X, Swaminathan S, Dagenais G, Gupta R, Mohan V, Lear S, Bangdiwala SI

SCFAs-mediated FFAR2 expression has been shown to trigger phosphoinositide 3-kinase (PI3K), signal transducer and activator of transcription (Stat)3, Stat5, and mammalian target of rapamycin pathways to promote ILC2s proliferation