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Ten-to-twelve-month-old beagle dogs weighing between 9.8 and 12.8 kg were purchased from YaDong Experimental Animal Research Centre, Nanjing, China

Nat Med 27:270278 Welniak LA, Blazar BR, Murphy WJ (2007) Immunobiology of allogeneic hematopoietic stem cell transplantation

Excessive Vitamin B12 intake effects While Vitamin B12 is generally safe to consume in small amounts and not known to be toxic to humans in some cases, taking high doses may sometimes lead to skin issues, like acne outbreaks and other skin-related reactions