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This discrepancy likely reflects the failure of mutant cells to progress to a fully differentiated phenotype, characterized by enhancer decommissioning and consequent loss of accessibility at distal and intronic regions (Wu et al, 2023)

Somalogic normalization and quality control Standard Somalogic normalization, calibration and quality control were performed on all samples 54,61,62,63

In addition, anchoring IL-2 and anti-CD137 on the surface of liposomes not only allows these immune agonists to rapidly accumulate in tumors, but also induces a large proliferation of CD8 + T cells and increases the intratumoral CD8/Treg ratio, thereby producing strong anti-tumor activity (144)

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