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reported that changes in the NP affected ion regulation within this disc region, which led to dysregulated cellular homeostasis and fibrotic changes to the tissue (Zhang et al., 2018)

Pregnancy and lactation represent relative contraindications given absence of human safety data in these populations despite reassuring preclinical reproductive toxicology studies

In addition, deletions in the 15q13.3 region that contains the CHRNA7 gene, which encodes the 7nAChR, are linked to a range of neurodevelopmental problems, including ASD [162, 163]

For example, Zepbound (tirzepatide) can lead to an average weight loss of 12% to 18%, depending on individual conditions