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c , HeLa cells expressing the indicated Integrator complex subunit were left untreated or treated with 4-NQO (5 M, 1 h) and then analyzed as in a

a , Representative proliferation plots of unstimulated mouse CD8 + T cells, or ex vivo-stimulated mouse CD8 + T cells that were either left untreated (non-arrested), arrested in the cell cycle using RO-3306, or released from RO-3306-induced arrest