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Noyce said that there isn't an agreed definition of "heavy use," but a ballpark figure is using more than 10 to 15 canisters more than once a week, citing his own research, while the Dutch Poison Centre classes puts it at inhaling 50 or more balloons in a single session

Beth states she has never taken any prescription medication long-term before, as she just started taking sertraline within the past few months from her primary care provider

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While this is not a randomized trial, it strongly indicates that prolotherapy can be effective for the types of chronic ligament and joint pain prevalent in EDS