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As emphasized by Zhao et al., the prolonged progression of AD before clinical symptoms emerge indicates that astrocytes may substantially contribute to disease pathogenesis at a single-cell resolution 12

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10.1016/s0197-4580(88)80117-9 [DOI] [PubMed] [Google Scholar] Devasagayam TP, Kamat JP, Mohan H, Kesavan PC (1996) Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species