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"It occurs in people whose B12 deficiency is caused by pernicious anemia," explains vitamin B12 expert and researcher Ralph Green, MD, PhD, a Distinguished Professor at the UC Davis School of Medicine

TPR domains typically mediate protein-protein interactions ( Ec CnoX, the TPR domain is composed of two similar subdomains with five -helices each that define a groove rich in charged residues ( FIGURE 1 Ec CnoX) whereas Cys63 is involved in the formation of mixed-disulfide complexes with substrate proteins, thereby protecting them from irreversible oxidation

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