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Although still sparsely investigated, both attenuated and increased Ca 2+ signalling have been demonstrated in various models of reactive astrogliosis, but so far without a clear understanding of the mechanisms involved (Shigetomi et al

The size of FA-CMC-GNA NPs was used as the evaluation criterion, with GNA concentration (A), water-to-oil ratio (B), homogenization time (C), and homogenization speed (D) selected as key factors for determining the optimal conditions

1) 2) CANCER : methotrexate is a structural analog of folic acid and at the high concentrations used in cancer chemotherapy it competitively inhibits the binding of dihydrofolic acid to dihydrofolate reductase (Furst et al., 2012)