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As already discussed, given the well-elaborated PK/ADME/tox profiles of phenformin in humans, we suggest holding phenformin as a candidate drug for preparedness in case of future outbreaks caused by coronaviruses and potentially other pandemic viruses

[DOI] [PMC free article] [PubMed] [Google Scholar] Carvalho CM, Chew EH, Hashemy SI, Lu J, Holmgren A

Conversely, PMs with higher degree of unsaturated fatty acids could be more pliable, and the presence of PUFA-PLs in the cell membranes is essential for fulfilling numerous cellular functions by increasing membrane fluidity