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Moreover, -syn overexpression in iPSCs compared with controls reduced the enzymatic activity of multiple lysosomal enzymes, including GCase, which is essential for the proper functioning of the autophagolysosome (Mazzulli et al., 2011, 2016)

Other methods of classifying the severity of TBI include using neuroimaging scans (CT, MRI, or PET) to measure brain swelling, diffuse Injury, or focal lesions

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