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349 Aging-related nuclear NAD + decline inhibits the mitochondrially encoded genes via the SIRT1-HIF-1-c-Myc pathway, while boosting NAD + levels rescues the mitochondrial function in old mice in a SIRT1-dependent manner

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A dose-related increase in the serum angiotensin converting enzyme level, indicative of pulmonary endothelial cell injury, was reported by Hollinger (1982), who administered carbon tetrachloride in vegetable oil at doses of 0.1 to 2.8 ml/kg body weight (159 to 4463 mg/kg body weight) to male Swiss-Webster mice

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