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In intervention studies, appropriate methodology includes the use of well-matched control groups, pre- and post-treatment testing, representative samples, sufficient sample sizes, random assignment, and procedures to eliminate bias

Fertility goals, baseline health conditions, medications, and psychological state all impact whether any experimental treatment would be considered

But a journal published online by the scientist in her basement that is peer-reviewed by her cousin is not the same as a study published in a high-impact, reputable medical journal edited and peer-reviewed by proven leaders in the field