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In Panel 1, DEPs are overexpressed in both CPZ and ND control groups and gene ontology (GO) enrichment analysis implicated these DEPs in intracellular ion homeostasis and transport, such as calcium-regulated proteins (e.g., sarcoplasmic/endoplasmic reticulum calcium ATPase 3SERCA3, inositol 1,4,5-Trisphosphate Receptor Type 1ITPR1, voltage-dependent anion-selective channelVDAC), glucose metabolism (e.g., enolase 1ENO1, aldolase CALDOC, aldehyde dehydrogenase 1 family member A1ALDH1A1), monoatomic anion epigenetic regulation of gene expression (e.g., high mobility group box 1HMGB1) (Fig

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