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If you think of an interleukin as the key and a cell receptor as the lock, dupilumab works by blocking the keyhole so that the key (IL-4 or IL13) is unable to get into the lock (the cell receptor)

Emmanuel C, Chiew YE, George J, Etemadmoghadam D, Anglesio MS, Sharma R, Russell P, Kennedy C, Fereday S, Hung J, Galletta L, Hogg R, Wain GV, Br A, Balleine R, MacConaill L, Palescolo E, Hunter SM, Campbell I, DeFazio A (2014) Genomic classification of serous ovarian cancer with adjacent borderline differentiates Ras pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver

Original price was: 100.00.Current price is: 80.00

Further studies have implied that HIV-1 icRNA is sensed and signals via the mitochondrial antiviral signaling protein (MAVS) pathway, inducing IFN-I-dependent pro-inflammatory responses in macrophages [41]