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With respect to the aprevo Cervical ACDF System, in the CY 2026 OPPS/ASC proposed rule, we questioned whether the aprevo insertion instrument, the integrated fixation screws, and/or the CAM components or parts may be considered a material or supply furnished incident to the service

Cost Comparison Let's look at the real costs over one year: B12 Injections: Doctor visits: $50-150 per visit 12-52 visits = $600-7,800/year Or self-injection supplies: $200-400/year Time cost: Travel and appointments B12 Oral Spray: Daily spray: Approximately $15-30/month = $180-360/year Time cost: 30 seconds per day at home The savings with oral spray are substantial, especially when you factor in time and convenience

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In post-marketing experience, angioedema and angioedema-like reactions were reported with parenteral methylcobalamin