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Dietary glutamine increases KG in vivo We next analysed metabolites from tumour tissues by liquid chromatographymass spectrometry (LC-MS) to evaluate changes in tumour metabolism as a result of the high glutamine diet

Knockdown of Gpx1 reduced the chondrogenic differentiation of ATDC5 cells by modulating intracellular GSH/oxidized GSH (GSSG) ratio 113

Notably, in vivo studies showed that mice treated with 0.3 MBq of the radioconjugate had a median survival of 55 days compared to 11 days in the control group, indicating a significant inhibition of tumor growth compared to controls [132]

In terms of gene expression, Chen et al