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These inhibitors not only prevent necroptotic cell death but also play a crucial role in suppressing NLRP3 inflammasome activation, thereby reducing neuroinflammation and neuronal damage in models of glutamate-induced excitotoxicity (113)

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Despite these challenges, glutaminolysis inhibition combined with other targeted therapies or immunotherapies remains under active investigation

Park SE, Dantzer R, Kelley KW, McCusker RH (2011) Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice