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doi: 10.7759/cureus.9853, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Hindle J

The timeline varies depending on what benefits you're looking for

Thus, even under normal cysteine and GSH levels, direct inhibition of GPX4 can induce ferroptosis

Among these, SGLT2 inhibitors stand out as the most successful example, having advanced from mechanistic insights to multiple large-scale RCTs and guideline-recommended first-line therapy