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Interestingly, ITZ itself is a CYP inhibitor (4043), so it is possible that autoinhibition of its own metabolizing CYP enzymes could potentiate toxicity over time

Biomolecules 12 , 197 (2022)

In addition, MedPAC recommends adding $2 billion to this MSNI pool of funds to help maintain the financial viability of Medicare safety-net hospitals and recommended to Congress transitional approaches for a MSNI policy