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BHB, the predominant ketone body in circulation, not only serves as an energy substrate, but also inhibits class I histone deacetylases, suppresses NLRP3 (nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing protein 3) inflammasome activation, and modulates nuclear factor kappa B (NF-B) activity, thereby influencing gene expression related to antioxidant defence, inflammation, and mitochondrial function [21, 37, 38]

There was no significant difference in test results between controls and patients without HE

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An area of growing interest involves the ability to not only enter the CNS but target specific immune cell types