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Synthetic lethal chemical screens in a panel of lung cancer cell lines and a normal epithelial cell line (BEAS-2B) with small-molecule drugs (n=22) targeting various oncogenic and metabolic pathways ( Supplementary Table 2 ) identified Erastin, an inhibitor of SLC7A11 and potent inducer of ferroptosis by blocking the uptake of cystine for GSH synthesis, that synergized with LDHB-specific siRNAs to suppress the viability of a subset of KRAS -mutant lung cancer cells (A549, H838, H460, H2122, and H2009), despite to a varied degree ( Figure 2a, b

Throughout evolutionary history, malaria-induced natural selection has profoundly influenced human genetic evolution, leading to the emergence of numerous genetic variations that confer resistance to the disease

In einer polysomnographischen Crossover-Studie an chronischen Insomniepatienten zeigten sich keine signifikanten Unterschiede gegenber Placebo

On the other hand, PAM is a bifunctional enzyme involved in the synthesis of hormones and neurotransmitters such as oxytocin, calcitonin, vasopressin, neuropeptide Y, GLP-1, and substance P, found in tissues such as the pituitary and adrenal glands