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In normo-weight subjects with MetS, there is a strong association of metabolic parameters with VCAM-1 and Asymmetric Dimethylarginine (ADMA) (a NOS inhibitor) [46], and the aggravation of insulin resistance is often accompanied by abnormal elevations of ICAM-1 and VCAM-1 [47], which decrease with the recovery of erectile function and effective treatment in ED patients [48]

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