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Theoretically, if homocysteine concentrations become extremely low, substrate availability for glutathione synthesis could also be reduced

Konecny has been treating excessive sweating of hands, underarm and feet, in addition of facial blushing

Nat Rev Endocrinol (2014) 10:13642

The majority of SAHHs/SIHHs analysed in this work containing a shortened C-terminus are (hyper-)thermophilic, confirming the assumption 36 that the length of the C-terminus correlates with the thermophilicity of the enzymes 46