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The results demonstrated that CAR-T, which has enhanced mitochondrial OXPHOS that utilizes fatty acids and reduced glycolytic activity, demonstrated more robust tumor elimination [115]

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Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

In hepatocarcinoma, anti-apoptotic miRNAs like miR-21, miR-221/222, and miR-155 are overexpressed, leading to the downregulation of tumor suppressor genes like phosphatase and tensin homolog deleted on chromosome ten ( PTEN ), cyclin-dependent kinase inhibitor 1B ( DKN1B)/p27 , cyclin-dependent kinase inhibitor 1C ( CDKN1C )/ p57 , and toll-like receptor 3 (TLR3)