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The gene for the coronavirus spike protein is inserted into an adenovirus that has been modified to render it harmless (it cannot cause COVID-19).Once administered into a muscle in the upper arm this modified adenovirus enters a cell, travels to the nucleus, and inserts the gene for making the spike protein into the host cell DNA

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Additionally, in many instances, protein-SOH formation has been detected by MS as an m / z shift equivalent to the addition of one oxygen atom (+16 Da)