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Tetrahedral DNA nanostructures (TDNs) as carriers loaded with antioxidant EGCG can efficiently penetrate the biological barrier, sustained release of drugs and antioxidant effects, and significantly improve the noise-induced hearing loss, which provides a novel delivery system for the treatment of inner ear diseases ( Different types of polyphenols may have different mechanisms in preventing cisplatin ototoxicity, and may act synergistically in enhancing its anticancer activity to reduce side effects.EGCG has antioxidant, anti-inflammatory, and inhibitory effects on Caspase-1 and NF-B, and curcumin regulates the Bcl-2/BAX ratio, inhibits the mitochondrial apoptotic pathway, and reduces Caspase-3 activation

However, the levels of therapeutic KBs and the specific effects of each ketone body have not been clearly elucidated

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Notably, AgNPs coated with PVP exhibited significantly greater biofilm inhibition compared to those stabilized with EC