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Both local application (directly at the injury) and systemic intramuscular injection proved effective

1 Introduction Ferroptosis is an iron-dependent regulated cell death driven by the peroxidation damage of phospholipid-containing polyunsaturated fatty acyl tails (PUFA-PLs) on the cell membrane or organelle membrane and subsequent membrane rupture ( Herein, we summarize the processes of ferroptosis in glioma, the current findings on ferroptosis in glioma, which include some of the pivotal regulators and pathways relevant to ferroptosis and the crosstalk between ferroptosis and other programmed cell death including apoptosis, autophagic cell death, necroptosis and pyroptosis