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Possible implications: Together, the novel findings in this study may have various important implications on muscle physiology and pathology and call for continuation studies on diverse physiological, pathological and therapeutic topics

Therefore, we performed our mitochondrial analyses upon 20 h of starvation to ensure sufficient nutrient stress in the absence of a loss of cell viability

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GPX4 specifically catalyzes the oxidative activity of lipid peroxides in a glutathione-dependent manner, thus protecting cells from the threat of ferroptosis [12, 17, 18]