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doi: 10.1016/j.ijsu.2015.11.010 145 OstoEDoytchevaPCortevilleCBueterMDorigCStivalaSet al

Attempts have been made to block the localization of Ras protein on the plasma membrane, to inhibit downstream oncogenic signaling via Kras effectors (including MEK1/2, Erk1/2 or Akt) targeting alone or in combination, and to inhibit Kras proteins directly