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This indicates that synthetic derivatives of natural products are usually more likely to be approved as drugs than themselves, and structural modifications will become a key bridge for successfully converting natural products into new pharmaceuticals [364]

Piperine was observed to directly reduce the phosphorylation of NF-B and the expression of NF-B target genes associated with RA-FLS proliferation, apoptosis inhibition, and inflammation

This review consolidates current knowledge and provides a mechanistic framework to guide therapeutic strategies that aim to intercept cancer resistance in the earliest and most reversible stages of its development

Accessed October 16, 2024