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Sinauer Associates

The great escape: Tumour cell plasticity in resistance to targeted therapy

Compared with 5-FU alone, the combination treatment (i.e., 5-FU + RSL3) significantly suppressed tumor regrowth after 5-FU cessation ( Figures 5FH )

It has been determined that a specific aminopeptidase-like enzyme is responsible for its low molecular stability in vitro, with a half-life of barely 15 minutes