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03 Research Highlights Cellular studies demonstrate increased lipolysis and fatty acid oxidation in differentiated adipocytes Animal models show reduced diet-induced obesity and improved insulin sensitivity with NNMT inhibition NAD+ metabolomics studies confirm restoration of cellular NAD+ and SAMe pools following NNMT blockade 04 Dosage Administration & Timing Oral administration (capsule or solution) or Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue

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Vitamin B12 is critical to that process

Because AOD-9604 acts via adipocyte-specific pathways, primary adipocytes or 3T3-L1 differentiated cells are typical matrices of choice