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Whether this unique pattern worsens the obese state or constitutes a favorable adaptation remains unclear, and the physiological and pathophysiological implications of the altered GH/IGF-I axis in obesity remain uncertain with GH neither being the cause nor the solution to reverse obesity

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What Guidelines Say About Lipid Management on Isotretinoin The American Academy of Dermatology (AAD) guidelines on acne management state that patients with pre-existing hypertriglyceridemia or a family history of lipid disorders should be counseled about dietary fat restriction and the possible addition of a lipid-lowering agent before starting isotretinoin [9]