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doi: 10.3389/fmed.2025.1624054 Received 06 May 2025 Accepted 13 October 2025 Published 19 November 2025 Volume 12 - 2025 Edited by Qi Dai, Wenzhou Medical University, China Reviewed by Jiancheng Mu, Sichuan University, China Man Hu, Wenzhou Medical University, China Updates Copyright 2025 AlHuthail

Reality: HSD, just like hypermobile Ehlers-Danlos syndrome (hEDS) and rarer types of EDS, can have significant effects on a persons health, whether this is related to their joints or to comorbidities

To overcome the limitations associated with placing cells in an artificial reducing environment, cysteine residues on galectins can be directly alkylated with iodoacetamide to form a stable thioether adduct that is resistant to further modification