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The cellular necrosis after an APAP overdose leads to release of cell contents, which includes molecules termed damage-associated molecular patterns (DAMPs) that can bind to pattern recognition receptors, e.g., toll like receptors, on macrophages and trigger formation of various cytokines and chemokines [8690]

731 Pharmacological inhibition of USP14 effectively reduces the level of NCOA4 to protect neurons from ferritin-mediated ferroptosis

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