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Ma C, Lv Q, Zhang K et al

Indole-3-acetic acid (IAA) promotes the expression of IL-22 and Reg3 through the aryl hydrocarbon receptor (AHR), enhancing intestinal mucosal integrity and mitigating alcohol-induced liver inflammation [209]

However, a recent preprint study indicated that endothelial ALOX15 might have a protective effect in mild lung thrombosis during sepsis-induced ALI [67], suggesting the possible multiple roles of ALOX15 in sepsis-induced ALI