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Around age 30, testosterone production begins to decline gradually, but factors like stress, poor sleep, weight gain, and certain medical conditions can accelerate that decline

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Available at: 1/5/2015

Aly et al used this approach to facilitate microglial transfection and increase plasmid nanoparticle delivery to brain parenchyma, resulting in sustained expression of the neurotrophic factor GDNF in PD-affected regions