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La sua sintesi avviene principalmente nel fegato e nei reni, da dove viene distribuita ai vari tessuti

10.1016/j.neuron.2013.02.011 Neuron 48 SheaT

During ROS binding, a large amount of lipid ROS with extremely strong oxidative activity is generated, which eventually leads to ferroptosis ( Ferroptosis in glioblastoma Ferrostatin-1, a ferroptosis inhibitor, acts as a free radical trapping antioxidant that inhibits intracellular ROS production and effectively suppresses glutamate-induced cell death in the mouse hippocampus

Fortunately, non-enzymatic agents, such as glutathione, and enzymatic agents, namely, several peroxidases, such as catalase, glutathione peroxidase and peroxiredoxin 2, are able to prevent OS damage