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BaP modulates aberrant DNA methylation or promoter hypermethylation in various tumor suppressor genes, which alters gene expression and contributes carcinogenesis

The key component of this complex is the NOX2 subunit, which facilitates the transfer of an electron from NADPH to molecular oxygen (O2), resulting in the production of the superoxide radical anion (O2)

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12 , 40 It also exhibited superior chemopreventive effects compared to aspirin, with significantly reduced gastrointestinal toxicity