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Interestingly, the DNA damage repair protein RRM2, often upregulated in NB to support oncogenicity, was upregulated across all conditions, and phosphorylation at the Ser-80 and Ser-86 sites was significantly downregulated by both combinations ( Supplementary Table S1 ) (4749)

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Therefore, coders should: Verify payer-specific administration requirements Review NCCI edits Confirm medical necessity Validate modifier usage Confirm HCPCS drug codes Furthermore, many payers require detailed drug documentation before reimbursing high-cost injectable medications